What Causes Autism?

There have been many theories put out as to what causes autism. Among concerns are the vaccinations' use of Thimerosal and the leaky gut hypothesis. But there are still a lot of unsolved issues.

There have been a lot of studies, but it is still unclear if a leaky gut causes autism. Researchers have shown that children with autism are more susceptible to having a leaky gut than typical kids. According to the notion, bacterial proliferation in the stomach causes a leaky gut. Undigested food particles may enter the circulation, triggering an immunological response and physical discomfort.

Autism may be caused by a variety of reasons, in addition to a leaky gut. According to studies, children with autism have higher metabolites in their urine and systemic circulation. These metabolites may have an immediate impact on neurodevelopment.

Being diagnosed with Asperger's syndrome does not make you "special." However, it can also indicate that you have some social anxiety. You may need assistance establishing eye contact, deciphering jokes, or reading body language. You could repeat actions or talk in a monotone

Some specialists think that Asperger's is influenced by environmental variables. These elements include assisted reproductive technology, maternal age, and maternal infections. These elements could have an impact on how children's brains grow.

Genetic factors may potentially contribute to autism. Single-gene congenital abnormalities may severely impact autism development. Brain cell communication is affected by genetics. Asperger's may result from this. More than 90% of violent offenders with Asperger's also had concomitant psychotic illnesses, according to a 2008 research.

Thimerosal, a substance used as a preservative and bacteriostatic agent, is a component in vaccines. Different vaccinations have different amounts of Thimerosal in them. In the United States, Thimerosal is now included in over 30 vaccinations.

The relationship between the vaccination ingredient thimerosal and autism has been examined in several research. They haven't discovered any association, however. The prevalence of autism is increasing. According to some studies, the rise in instances is due to altered diagnostic standards and more public awareness of the condition.

The Immunization Safety Review Committee reviewed numerous research on the link between immunizations and autism. It was discovered that vaccinations raised the likelihood of developing autism. However, there were no reliable significant connections. The committee also found insufficient evidence in the research to establish a causal relationship between Thimerosal and autism.

Numerous studies have hypothesized that autistic individuals' urine may include higher concentrations of opioid peptides. Additionally, they suggested that these peptides could contribute to the development of autism.

Researchers developed a technique to examine autistic children's urine to find endogenous opioids. The findings of their investigation imply that whereas opioid peptides are absent from the urine of typical children, they are present in the urine of autistic children.

Mutations in the DPPIV gene are considered to be the primary source of endogenous opioids. DPPIV controls the mechanisms involved in inflammation. Increased amounts of endogenous opioids may result from the overuse of exogenous opioids saturating the DPP4 enzymes. However, women have less DPPIV activity than males. The reduced immunological state is linked to lower DPPIV activity.

MicroRNA-128 has been shown to control neurogenesis throughout development. In the growing neocortex, these tiny RNA molecules regulate the division of neural progenitor cells (NPCs).

MiR-128 may control differentiation in addition to controlling NPC proliferation. The differentiation of NPCs into neurons is aided by overexpression of this small RNA. This RNA is inhibited, which reduces the number of neurons and suppresses NPC growth.

MiR-128 expression is rising in the growing mouse brain, according to recent research. Nevertheless, it must be made clear how this impacts cortical development. According to a specific study, improper cortical development may be caused by aberrant miR-128 expression. In this investigation, Zhang, Kim, and associates investigated the function of miR-128 in the developing mouse brain.

On E14.5 mouse embryo brain coronal slices, miR-128 LNA in situ hybridization and immunofluorescence analysis of the neural stem cell marker NESTIN were carried out to examine the function of miR-128 in development. At E14.5, cortical layers were shown to have miR-128. Additionally, an immunofluorescence examination of the NPC marker NESTIN revealed that the VZ/SVZ cells had higher levels of miR-128 expression.